系统性硬化症患者雷诺现象的管理实践:来自美国社区实践的现实数据
Gulsen Ozen1, Sofia Pedro2, Robyn T Domsic3
1From the University of Iowa Health Care, Iowa City, IA.
概括
在全身性硬化症 (SSc) 患者中,雷诺现象 (RP) 的管理显示药物使用率低,维护率差. 需要对医生进行教育和更新指南,以改善社区类风湿病的RP治疗.
科学领域:
- 类风湿病学 类风湿病学
- 临床实践 临床实践
- 药理学 药理学是指药理学的学科.
背景情况:
- 系统性硬化症 (SSc) 经常涉及雷诺现象 (RP),一种影响周围循环的疾病.
- 有效的RP管理对于预防并发症和改善SSc患者的生活质量至关重要.
- 当前社区类风湿病学家对SSc患者的RP管理实践需要详细描述.
研究的目的:
- 在美国社区的风湿病学家中描述系统性硬化症 (SSc) 患者的雷诺现象 (RP) 管理实践.
- 评估SSc患者对RP的纵向药物使用情况.
- 为了确定与RP药物启动和使用相关的因素.
主要方法:
- 来自FORWARD数据库 (1999-2023) 的成年SSc患者的回顾性分析.
- 通过半年问卷对RP药物使用进行纵向评估.
- 多变量安德森和吉尔·考克斯的比例模型用于评估与RP药物使用相关的因素.
主要成果:
- 在270名SSc患者中,有61%接受了RP药物治疗;维持率低 (<33%).
- 通道阻断剂是最常见的第一线疗法 (75%),但它们的使用量下降.
- 自2019年以来,固酶-5抑制剂 (PDE5i) 的使用增加;高血压,肺部疾病和社会经济因素影响了启动.
结论:
- 在社会环境中,SSc患者的整体RP药物使用和维护在社区环境中是不理想的.
- 在RP药物中转移的模式包括增加PDE5i使用.
- 加强教育和指导方针的制定是必要的,以优化社区风湿病学家的RP管理.
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