产品特征的差异和输血颗粒细胞的临床使用:最好的合作研究
Lorna Cain1,2, Charles Lafrance3,4,5, Suzy Morton6,7
1Haematology/Transfusion Medicine, NHS Blood and Transplant and Oxford University Hospitals NHS Trust, Oxford, UK.
Transfusion
|May 15, 2025
概括
颗粒细胞输血的疗效尚不确定,但生产方法各不相同. 这项研究调查了各种颗粒细胞制造工艺,突出了捐赠者可用性和保质期等挑战,这对于未来的临床试验至关重要.
科学领域:
- 血液学 血液学 血液学
- 输血医学 输血医学
- 细胞疗法 细胞疗法
背景情况:
- 颗粒细胞输血的临床益处尚不清楚,可能存在剂量-反应关系.
- 颗粒细胞的生产主要是利用亚菲雷斯,但替代制造方法正在获得引力.
研究的目的:
- 调查和描述当前的颗粒细胞制造和临床使用实践.
- 确定与颗粒细胞生产和输血相关的操作考虑和挑战.
主要方法:
- 对参与颗粒细胞生产和/或使用的中心进行了详细的调查.
- 该调查涵盖了颗粒细胞制造,规格,临床应用,操作方面和数据收集.
主要成果:
- 包括15个生产/使用颗粒细胞的中心,采用阿菲雷斯,聚合布菲外套,单个布菲外套或残留白细胞单元.
- 报告的成年人平均剂量因生产方法而异;用G-CSF和/或类固醇进行非捐赠.
- 全血原粒细胞提供了更短的输送时间,但供体可用性,短保质期和缺乏疗效证据是关键挑战.
结论:
- 颗粒细胞生产方法存在显著差异.
- 这些生产差异对于设计和解释未来关于颗粒细胞疗效的国际临床研究至关重要.
相关概念视频
01:15Differentiation of Common Myeloid Progenitor Cells
3.1K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.1K
01:30Classification of Leukocytes
1.3K
Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
1.3K
02:45Blood Transfusion and Agglutination
10.6K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.6K