相关实验视频

Updated: May 6, 2026

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
11:34

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Published on: May 5, 2014

13.7K

通过先进的虚拟查方法识别人类诺罗病毒感染的潜在3CLpro抑制剂调节剂

Shovonlal Bhowmick1, Tapan Kumar Mistri2, Mohammad K Okla3

  • 1Departement of Drug Discovery, SilicoScientia Private Limited, Bengaluru, India.

Journal of biomolecular structure & dynamics
|May 15, 2025
PubMed
概括

研究人员选了人类诺罗病毒 (HuNoV) 3CLpro抑制的小分子. 确定了三个有前途的化合物,显示出强大的结合亲和力和开发HuNoV治疗药物的潜力.

关键词:
3CLPro 3CLPro是3CLPro的产品之一.诺罗病毒是一种病毒.自由能源的景观.分子对接的分子对接.分子动力学分子动力学虚拟选 虚拟选 虚拟选

更多相关视频

Production of Human Norovirus Protruding Domains in E. coli for X-ray Crystallography10:46

Production of Human Norovirus Protruding Domains in E. coli for X-ray Crystallography

Published on: April 19, 2016

8.6K
Alternative In Vitro Methods for the Determination of Viral Capsid Structural Integrity12:57

Alternative In Vitro Methods for the Determination of Viral Capsid Structural Integrity

Published on: November 16, 2017

8.1K

相关概念视频

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
129
Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible...
55
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
73