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Updated: May 16, 2025

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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对布鲁顿的氨酸激酶与非共价抑制剂的突变诱导的结合变化进行计算洞察

Justice Josiah Mallen1, Shilpa Sharma1, Md Nazmul Hasan1

  • 1Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.

Journal of biomolecular structure & dynamics
|May 15, 2025
PubMed
概括

布鲁顿的氨酸激酶 (BTK) 突变降低了慢性淋巴细胞白血病 (CLL) 的非共价抑制剂疗效. 这项研究揭示了这些突变如何破坏药物结合,为下一代BTK抑制剂提供了洞察力,以克服耐药性.

关键词:
布鲁顿的铁氨基激酶.慢性淋巴细胞白血病 慢性淋巴细胞白血病分子动力学模拟模拟突变是一种突变.非共价抑制剂的非共价抑制剂

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