在主导瘤中通过空气空间的同时传播会影响同步多重原发性肺腺癌的预后
1Department of Thoracic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
概括
瘤通过空气空间传播 (STAS) 在两个初级肺腺癌 (bi-STAS) 显著恶化了早期同步多重初级肺腺癌 (sMPLA) 的预后. 这一发现与外科手术方法无关,强调了STAS评估对风险分层的重要性.
科学领域:
- 胸部外科手术 胸部外科手术
- 肺部医学 肺部医学
- 在瘤学瘤学.
背景情况:
- 在同步多重原发性肺腺癌 (sMPLA) 中,通过空气空间 (STAS) 扩散瘤的预后意义尚不清楚.
- 早期的sMPLA预后受到各种因素的影响,需要进一步研究特定的病理标志物.
研究的目的:
- 为了评估STAS在早期阶段的预后影响sMPLA.
- 评估STAS和外科手术策略对患者结果的综合影响.
主要方法:
- 在2012-2018年间诊断出cT1-3N0M0sMPLA的131名患者的回顾性分析.
- 使用最小绝对收缩和选择操作员 (LASSO) 回归识别的预测变量.
- 使用Cox比例风险和Fine & Gray竞争风险回归模型分析的生存结果.
主要成果:
- 在51.9%的患者中存在STAS;16.0%的患者在两种瘤中都有STAS (双STAS).
- 双STAS独立预测了较差的整体存活率 (HR=3.78) 和无复发存活率 (HR=3.99).
- 双STAS患者的存活率显著降低,复发率更高,无论手术程度如何 (切手术与亚叶切除).
结论:
- 同时双STAS是一种强大的独立预后标志物,用于早期sMPLA.
- 在所有初级瘤中进行全面的STAS评估对于准确的术后风险分层至关重要.
- 手术策略对双STAS患者的结果的影响有限.
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