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探索APOEε4等位基因与健康成年人肠道微生物群组成和功能之间的关系

C Bressa^1,2, R González-Soltero^1,3, M Tabone^1,3

¹Masmicrobiota Research Group, Madrid, Spain.

|May 15, 2025

概括

APOE4基因变异与健康成年人的肠道细菌变异有关,可能会影响新陈代谢和免疫反应. 这些微生物差异可能会影响与APOE4.4相关的健康结果.

科学领域:

微生物组研究的研究.
人类遗传学人类遗传学
代谢健康代谢健康

背景情况:

阿波利波蛋白E ε4等位基因 (APOE4) 是神经退行性和心血管疾病的重要危险因素.
肠道微生物群在宿主新陈代谢和免疫力中的作用已经确立,但其与健康个体的APOE基因型的相互作用尚不清楚.

研究的目的:

研究APOE基因型与健康成年人肠道微生物群组成和功能之间的关联.
为了确定与APOE4等位基相关的微生物和代谢差异.

主要方法:

在77名健康的西班牙成年人身上进行了APOE基因型鉴定.
使用16S rRNA基因测序分析了便微生物群组成.
使用PICRUSt2预测了微生物功能;也评估了身体组成和身体活动.

主要成果:

携带APOE4的Megamonas和Eubacterium菌群的丰富性减少,并增加了未表征的Puniceicoccaceae属.
虽然E. brachy群的丰度与脂肪度相关,但在APOE基因型之间没有发现整体体质成分的显著差异.
与APOE4相关的微生物群显示了功能途径的改变,包括胡卜素生物合成和三糖代谢中的丰富,以及托生物合成和酸盐生产中的枯竭.

结论:

APOE4载体具有独特的肠道微生物群特征,具有独特的功能能力.
这些微生物差异可能代表了受APOE4基因型影响的对代谢和氧化挑战的适应.
肠道微生物组在塑造APOE4相关的表型方面发挥着至关重要的作用,这表明了潜在的治疗点.

关键词:

在APOEε4等位基因中,身体组成身体组成我们的肠道微生物群.健康的成年人健康的成年人代谢功能的代谢功能

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