在密集的血压控制上,申伊申的有效性:用现实世界的数据模拟一个随机的目标试验
Xiao-Jie Wang1,2, Yuan-Long Hu2, Jia-Ming Huan2
1Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, 999078, China.
Chinese journal of integrative medicine
|May 15, 2025
概括
申伊申开 (XYD) 改善了密集血压 (BP) 控制,并减少了高血压患者的再入院. 这项研究为高血压管理中的补充疗法提供了现实世界的证据.
科学领域:
- 心血管医学 心血管医学
- 综合医学是一个整体的医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 高血压仍然是一个重大的全球健康挑战,需要新的治疗策略.
- 传统中医 (TCM) 提供潜在的补充方法来管理复杂的疾病,如高血压.
- 申伊申开 (XYD) 是一种TCM配方,具有潜在的抗高血压特性.
研究的目的:
- 评估申伊申开 (XYD) 作为高血压的补充治疗的临床有效性.
- 评估XYD对实现密集血压 (BP) 控制和降低6个月全因再入院率的影响.
主要方法:
- 使用医院电子病历 (2019-2023) 模拟了一个务实的临床试验设计.
- 符合条件的参与者 (年龄≥40,缩血压≥140mmHg) 被分为治疗组 (XYD+抗高血压疗法) 和对照组 (仅抗高血压疗法).
- 主要结果:在出院时达到密集血压控制率;次要结果:所有原因的6个月再入院率.
主要成果:
- 该研究包括3,302名患者 (359名接受治疗,2,943名控制).
- XYD组显示了密集血压控制的显著更高率 (17.5%与8.09%,OR=2.29,P<0.001),特别是在那些具有高水平的同类半氨酸.
- 在XYD组中,所有原因的6个月再入院率较低 (HR=0.58,P=0.019),灵敏度分析证实了强有力的发现.
结论:
- 申伊申开 (XYD) 证明了作为一种补充疗法,可以增强高血压患者的密集血压控制的潜力.
- 这些发现支持XYD在减少住院再接收方面的作用,为整合性治疗策略提供了有价值的现实世界的证据.
- 这项研究指导了对高血压管理的补充和替代疗法的选择.
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