相关实验视频
Updated: May 17, 2025
10:19
A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
14.2K
益生菌Lactobacillus物种在阴道上皮质细胞殖民期间调节免疫反应
Marisa Valentine1, Diletta Rosati2, Axel Dietschmann3
1Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Jena, Germany.
The Journal of infectious diseases
|May 15, 2025
概括
益生菌乳酸菌可以通过调节免疫反应来影响 vulvovaginal candidiasis (VVC). 一些物种可能会诱导有益的炎症,但需要进一步的研究来确认它们对VVC的治疗潜力.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 妇女健康 妇女健康
背景情况:
- Vulvovaginal candidiasis (VVC) 是一种常见的真菌感染,涉及Candida albicans和阴道失生症.
- 乳酸菌种在健康的阴道微生物群中占主导地位,可能会抑制Candida albicans.
- 益生菌乳酸菌被研究用于VVC治疗,但它们的免疫作用尚不清楚.
研究的目的:
- 为了研究益生菌乳酸菌如何影响阴道上皮质和免疫反应,在虫白菌感染期间.
- 在VVC模型中探索特定益生菌乳杆菌物种对炎症途径的影响.
主要方法:
- 在体外使用的Candida albicans的阴道上皮膜感染模型.
- 刺激原发性人体免疫细胞与来自受感染的阴道上皮细胞的超级细胞.
主要成果:
- 大多数测试的益生菌乳酸菌减少了Candida albicans引起的上皮损伤.
- 利莫西拉科巴西勒斯发酵和Lacticaseibacillus paracasei诱导了独立于Candida albicans的炎症反应.
- 益生菌乳酸菌的微分调节的中性粒细胞功能,包括杀死Candida albicans和产生活性氧物种.
结论:
- 阴道上皮和免疫反应受到特定益生菌乳球菌种及其相互作用的显著影响.
- 由某些益生菌诱导的受控炎症可能会增强中性粒细胞的功能.
- 需要进一步调查,以确定这些益生菌诱导的免疫调节是否减轻VVC免疫病理.
相关概念视频
01:26Defense Mechanism Against Infection
5.7K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
5.7K
01:18Surface Membrane Barriers
747
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
747