患有非关节炎前部缺血光学神经病变的患者中缺血性中风的风险:一项大数据研究
Rachel Shemesh1, Hadar N Rosenblatt, Ruth Huna-Baron
1Sheba Medical Center (RS, RH-B, OZ), Goldschleger Eye Institute, Tel Hashomer, Israel; Faculty of Medicine (RS, RH-B, OZ), Tel-Aviv University, Tel-Aviv, Israel; Ophthalmology Department (HNR, NL), Kaplan Medical Center, Rehovot, Israel; Ophthalmology Department (AK), Tel-Aviv Sourasky Medical Center, School of Medicine, Tel Aviv University, Tel Aviv, Israel; and Hadassah and Hebrew University Medical School (NL), Jerusalem, Israel.
概括
患有非动脉炎前部缺血性视觉神经病变 (NAION) 的患者面临更高的缺血性中风风险,即使没有其他血管风险因素. 这突显了NAION,中风和动脉狭窄之间的潜在联系.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 血管医学 血管医学
背景情况:
- 非动脉炎前部缺血性视神经病变 (NAION) 是一种影响视力的疾病.
- NAION与缺血性中风风险之间的关系,特别是关于动脉狭窄症 (CAS),需要进一步调查.
研究的目的:
- 在被诊断为NAION的患者中调查缺血性中风的发生.
- 评估NAION和CAS之间作为缺血性中风风险因素的关联.
主要方法:
- 从2009年至2019年进行了一项回顾性,全国性,基于人口的研究.
- 包括605名没有先前缺血性中风的NAION患者,与以色列最大的医疗保健网络的较大对照组相匹配.
- 分析了缺血性中风发生率和CAS流行率的数据.
主要成果:
- 与对照组相比,NAION患者的大血管 (18.7%与14.7%) 和小血管 (4.8%与3.1%) 缺血性中风发病率较高.
- 在研究和随访期间,在NAION患者中观察到高CAS患病率.
- 多变量分析显示,在NAION患者中,两种类型的缺血性中风的危险比率都增加了 (大血管的HR为1.5,小血管的HR为1.56).
结论:
- 一个NAION诊断与缺血性中风的发病率增加有关,独立于其他血管风险因素.
- 这些发现表明NAION,缺血性中风和CAS之间存在潜在的三元关系.
- 由于这种关联,需要考虑针对CAS的NAION患者的特定管理策略.
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