综合风险模型显示,个人化乳腺癌风险评估在印尼人口中的可行性:一个病例/对照研究
Bijak Rabbani1, Sabrina Gabriel Tanu1, Kevin Nathanael Ramanto1
1PT Nalagenetik Riset Indonesia, Jakarta, Indonesia.
PloS one
|May 15, 2025
概括
这项研究表明,结合乳腺癌风险模型,整合临床和遗传因素,对印度尼西亚妇女有效. 这些多方面的方法提高了风险预测准确性,而不是单因素模型.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 全球乳腺癌发病率正在上升,特别是在印度尼西亚.
- 有效的基于风险的查对于早期检测和管理至关重要.
- 现有的风险评估模型需要在不同的人口群体中进行验证.
研究的目的:
- 评估临床 (Gail) 和多基因 (Mavaddat) 乳腺癌风险模型在印尼人口中的适用性.
- 开发和评估一个综合风险评估工作流程.
- 为了比较单因素与多面风险模型的预测准确度.
主要方法:
- 一项涉及305名印尼妇女的病例控制研究.
- 开发一个个性化的风险评估工作流程,整合盖尔和马瓦达特模型.
- 使用接收器操作特征曲线 (AUC) 下面的面积来评估模型性能.
主要成果:
- 盖尔 (AUC:0.67) 和马瓦达特 (AUC:0.67) 模型在印度尼西亚环境中都保持了预测准确度.
- 综合风险模型实现了更高的AUC,为0.70.
- 多面性方法显示出优越的预测性能,而不是单因素模型.
结论:
- 盖尔和马瓦达特风险模型适用于印度尼西亚的人口.
- 综合风险模型为这一人口群的乳腺癌风险评估提供了更准确和更强大的框架.
- 这些发现支持印尼实施基于风险的综合查策略.
相关概念视频
Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
106
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
106
Cancer Survival Analysis
311
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
311
Hazard Ratio
72
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
For example, in a clinical trial...
72
Probability Laws
38.5K
Overview
38.5K


