术前营养状况对术后肺移植患者肺功能障碍的影响
Ryo Takahashi1, Midori Miyagi2, Tatsuma Okazaki2
1Department of Rehabilitation Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; Sendai Clover Clinic, Sendai, Japan.
Nutrition (Burbank, Los Angeles County, Calif.)
|May 15, 2025
概括
手术前的营养状况显著影响肺移植后的吞功能. 较差的营养标志物,比如较高的控制营养状况 (CONUT) 评分,预测肺移植接受者手术后食障碍的风险更高.
科学领域:
- 移植医学 移植医学
- 营养科学 营养科学
- 吞障碍 吞障碍 吞障碍
背景情况:
- 手术后的消化不良是肺移植 (LTx) 后的一个重大并发症.
- 手术前的营养状况越来越被认为是影响手术结果的关键因素.
- 评估LTx前的营养状况可能有助于识别患有吞困难风险较高的患者.
研究的目的:
- 研究肺移植患者手术前营养状况与手术后食障碍的严重程度之间的关联.
- 确定特定的营养指标,预测LTx.之后的消化不良风险.
主要方法:
- 对65名肺移植接受者的回顾性分析.
- 使用控制营养状况 (CONUT) 评分和全球营养不良领导倡议 (GLIM) 标准评估术前营养状况.
- 在第14天使用功能性口服摄入量表 (FOIS) 评估术后消化障碍;用于因子分析的二进制逻辑回归.
主要成果:
- 手术后的消化不良 (39/65患者) 与年龄较小,女性性别,双 LTx,更长的 ICU 停留,机械呼吸,更长的手术,气管切除,ECMO,PAH,更高的 CONUT 评分和 GLIM 定义的营养不良有关.
- 手术前的CONUT评分是术后食障碍的唯一独立预测因子 (P=0.026,OR=0.221).
结论:
- 手术前的营养状况,特别是根据CONUT得分所示的营养状况,在肺移植后保持吞功能方面发挥着至关重要的作用.
- 在LTx之前优化营养状况可能是缓解术后消化不良的一个关键策略.
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