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Updated: Jul 29, 2026

Protocol for Isolation of Primary Human Hepatocytes and Corresponding Major Populations of Non-parenchymal Liver Cells
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将悬浮类型的人类原发性肝细胞转化为可板类型,用于作为体外药理动力学模型

Raghda Shahin1, Yoko Sakai2, Kotaro Shirai3

  • 1Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan; Department of Clinical Pharmacy, Faculty of Pharmacy, University of Sadat City, Sadat City, Egypt.

Drug metabolism and pharmacokinetics
|May 15, 2025
PubMed
概括

这项研究引入了一种新的方法,以培养悬浮的人类初级肝细胞 (sHPHs) 作为可板细胞. 这一突破为药物代谢和转运体研究提供了更实惠和可复制的体外模型.

关键词:
诱导 CYP450 的诱导.肝细胞附着:细胞与细胞的接触.在体外的药理动力学模型.悬浮类型是人类原发性肝细胞.

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相关概念视频

Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...