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Updated: May 8, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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为药物发现利用计算工具:一种综合计算方法来识别潜在的BACE-1抑制剂

Usman Shareef1, Muhammad Kazim Zargaham1, Ahsan Ibrahim1

  • 1Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad, 44000, Pakistan.

Journal of molecular graphics & modelling
|May 15, 2025
PubMed
概括

这项研究通过计算选β-分泌酶1 (BACE-1) 抑制剂来确定阿尔茨海默病 (AD) 的潜在候选药物,β-分泌酶1 (BACE-1) 是粉样蛋白斑块积聚的关键因素. 发现了具有良好的安全性概况的有前途的化合物,为AD治疗研究提供了具有成本效益的方法.

关键词:
接收人 接收人在BACE-1的基础上.模拟MDMD的模拟分子对接是分子对接.制药学模型的建模.虚拟选是一个虚拟的选.

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