利用在抗微生物药物耐药性机制,检测和策略方面的进展来打击抗微生物药物耐药性
Ritik Kumar Thakur1, Kaushal Aggarwal1, Nayan Sood1
1Department of Pharmaceutics, ISF College of Pharmacy, GT Road, Moga 142001, Punjab, India.
The Science of the total environment
|May 15, 2025
概括
抗菌素耐药性 (AMR) 是一个主要的全球威胁. 本综述详细介绍了AMR机制,检测方法,以及人工智能和纳米技术等创新干预措施,用于未来的监测和治疗.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 抗微生物药物耐药性 (AMR) 构成了重大的全球卫生危机,降低了抗微生物药物的有效性.
- 抗药性耐药性日益普遍,导致全球的发病率,死亡率和经济负担增加.
- 了解抗生素发现和耐药性的历史背景对于应对当前的挑战至关重要.
研究的目的:
- 提供对抗微生物耐药性 (AMR) 的全面审查.
- 总结各种病原体中的AMR机制,并详细介绍细菌耐药性机制.
- 探索目前和未来的AMR检测和缓解策略.
主要方法:
- 审查关于抗生素发现和耐药性的历史数据.
- 合成关于细菌,真菌,病毒和寄生虫中的AMR机制的信息.
- 对各种AMR检测方法 (表型,基因型,高级) 的分析.
- 探索创新的AMR缓解策略和临床试验.
主要成果:
- 详细概述AMR机制,重点关注细菌.
- 关于AMR检测和监测的既定和新兴方法的概述.
- 讨论尖端干预措施,包括CRISPR-Cas,纳米技术,人工智能和One Health方法.
- 包括与AMR相关的已完成和正在进行的临床试验.
结论:
- 抗药性耐药性需要紧急的全球行动和跨学科的合作.
- 创新技术为未来的AMR监测和治疗提供了有希望的途径.
- 整合研究和临床见解对于开发有效的抗AMR解决方案至关重要.
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