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Updated: May 17, 2025

Use of Alu Element Containing Minigenes to Analyze Circular RNAs
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Ku限制了RNA诱导的先天免疫力,使灵长类动物能够扩展Alu

Yimeng Zhu1,2, Angelina Li1,2,3, Suvrajit Maji4,5

  • 1Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Nature
|May 15, 2025
PubMed
概括

Ku在人类细胞中是必不可少的,但不是小鼠,通过与灵长类动物特有的Alu元素结合来限制有害的dsRNA诱导的先天免疫力,这解释了其更高的表达和重要作用.

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