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Characterization of Human Monocyte Subsets by Whole Blood Flow Cytometry Analysis
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在儿科急诊护理中评估单细胞分布宽度.

Luisa Agnello1, Caterina Maria Gambino2, Fabio Del Ben3

  • 1Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine, and Clinical Laboratory Medicine, University of Palermo, Palermo, Italy.

Clinica chimica acta; international journal of clinical chemistry
|May 15, 2025
PubMed
概括

单细胞分布宽度 (MDW) 可能有助于在急诊室识别儿科感染. 虽然MDW值随着疾病严重程度的增加而增加,但年龄会影响毒症儿童的诊断清晰度.

关键词:
孩子 孩子 孩子 孩子感染 感染 感染在 MDW MDW 中.儿科 儿科 儿科败血症 这是一种败血症.

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科学领域:

  • 儿科中的生物标志物
  • 血液学 血液学 血液学
  • 传染病诊断 传染病诊断 传染病诊断

背景情况:

  • 儿科败血症由于与年龄相关的变化而带来诊断挑战.
  • 单细胞分布宽度 (MDW) 是成年人潜在的败血症生物标志物,但其儿科实用性尚不清楚.
  • 这项研究调查了MDW在诊断急诊部 (ED) 儿科感染中的作用.

研究的目的:

  • 评估单细胞分布宽度 (MDW) 的临床有用性,用于向ED提交的儿科患者.
  • 评估MDW在区分儿童感染,败血症和冲击中的表现.
  • 探索MDW诊断准确性的与年龄相关的差异.

主要方法:

  • 在ED中对儿科患者 (<18岁) 的回顾性观察研究.
  • 分类为对照,感染,败血症和冲击组.
  • 跨群体的MDW比较,按年龄分层 (≤6岁和>6岁),用ROC曲线分析.

主要成果:

  • 随着疾病的严重程度,MDW值通常会增加,在休克时最高.
  • 在MDW中,感染和败血症之间存在显著的重叠,特别是在较小的儿童 (≤6岁).
  • 在年龄较大的儿童 (>6岁) 中,MDW的逐步增加更明显;感染与非感染的AUC为0.73.

结论:

  • MDW是一种可访问的生物标志物,可以帮助在紧急情况下识别儿科感染.
  • MDW的诊断性能随年龄而变化,在年龄较大的儿童中显示出更大的效用.
  • 进一步的研究可能会完善MDW在儿科败血症诊断中的作用.