英格兰的抗菌素耐药性趋势,预测因素和负担:使用临床实践研究数据链接从2015年到2021年的回顾性研究
Amer Taie1, Maria Gheorghe2, James Amos1
1Pfizer R&D UK Ltd, Tadworth, UK.
International journal of antimicrobial agents
|May 15, 2025
概括
抗菌素耐药性 (AMR) 显著增加了住院时间,成本和死亡率. 这种日益严重的威胁迫切需要改变医疗保健政策,以应对不断升级的负担.
科学领域:
- 医疗保健服务研究 医疗服务研究
- 传染性疾病 传染性疾病
- 卫生经济学 卫生经济学
背景情况:
- 抗菌素耐药性 (AMR) 对全球健康构成了关键挑战.
- 了解AMR的负担对于制定有效的卫生政策至关重要.
- 英格兰国家卫生服务 (NHS) 提供了一个大规模的环境来研究AMR的影响.
研究的目的:
- 调查AMR在英国NHS中的趋势,预测因素以及AMR的临床和经济负担.
- 量化与AMR感染相关的过度医疗利用率和死亡率.
- 为旨在减轻AMR的政策干预提供证据.
主要方法:
- 在英格兰的1,036,850名住院患者 (2015-2021) 进行了回顾性队列研究.
- 使用ICD-10代码识别耐药感染.
- 倾向性得分匹配用于比较AMR和非AMR感染患者.
- 分析住院时间,再住院,总住院费用和死亡率.
主要成果:
- 与AMR感染相关的额外停留时间为9.2天,每个患者的费用为3441英.
- 增加的死亡率:AMR的3.2% (1年),6.3% (3年),7.3% (5年).
- 在AMR感染患者中,较早死亡率 (27%) 和再住院 (26%) .
- 2015年至2020年间,AMR呈现出10%的比例增长.
结论:
- 抗菌药物耐药性对医疗保健系统构成重大和不断升级的威胁.
- 抗药性耐药性感染导致大量的过度医疗保健使用,包括更长的住院时间和更高的成本.
- 抗菌药物耐药性与患者死亡率和再入院率的增加有关,突出显示需要采取紧急行动.
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