对BRCA1/2携带者的男性亲属中级查采用的障碍和促进因素的多层次分析:一种定性研究
G Ongaro1,2, J G Hamilton1,3, V Groner3
1Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Psycho-oncology
|May 15, 2025
概括
对于BRCA1/2基因变异的级联查 (CS) 被男性亲属不足使用. 障碍包括认识不足和后勤问题,而提供者的建议和感知到的好处可以促进遗传性癌症家族的吸收.
科学领域:
- 遗传学和基因组学 遗传学和基因组学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 致病性BRCA1/2变体增加了乳腺,卵巢,前列腺和胰腺癌的风险.
- 推级别查 (CS) 用于识别有风险的亲属,但其吸收率低于最佳,特别是在男性中.
研究的目的:
- 探索女性BRCA1/2携带者的男性一级亲属 (FDR) 中的CS的障碍和促进因素.
- 了解影响BRCA阳性家庭中风险男性CS实施的因素.
主要方法:
- 有关11名未经测试的男性FDR的半结构面试的定性研究.
- 以健康行动过程方法为指导的专题分析,以确定个人,人际关系,提供者和环境因素.
主要成果:
- 关键障碍:有限的认识,不准确的知识,后勤问题和心理问题.
- 促进因素:生命阶段,测试结果可操作性,感知到的预防益处,家庭支持和直接提供者的建议.
结论:
- 结果为有针对性的干预提供信息,以改善遗传性癌症综合征中的CS吸收.
- 针对性别的教育,公众宣传活动和直接提供者参与对于加强男性参与CS至关重要.
关键词:
这就是BRCA1的原因.这就是BRCA2的原因.癌症 癌症 癌症 癌症 癌症级联查是指分级查.级联测试 级联测试 级联测试 级联测试家庭癌症风险家族癌症风险性别特定的癌症预防.基因检测 基因检测是指基因检测.遗传性癌症是一种遗传性癌症.瘤学 在瘤学方面.更多相关视频
08:15gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
Published on: October 6, 2014
13:04In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
Published on: October 14, 2015
相关概念视频
Longitudinal Research
11.8K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
11.8K
Criteria for Causality: Bradford Hill Criteria - II
171
The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
171
Cancer Survival Analysis
313
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
313
