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Updated: May 17, 2025

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[在帕金森病中对非运动性症状的亚thalamic核深度大脑刺激的长期疗效]

J M Chu1, L Wu1, J H Chen2

  • 1Department of Neurology, the First Affiliated Hospital, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Guangzhou 510080, China.

Zhonghua yi xue za zhi
|May 15, 2025
PubMed
概括

脑下核深度大脑刺激 (STN-DBS) 在3年内改善了帕金森病 (PD) 患者的非运动症状. 然而,超过10年的长期疗效显示认知能力下降,情绪症状恢复到基线.

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
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