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疟疾相关急性损伤的动物模型

Collins Ojonugwa Mamudu¹, Rafael Polidoro², Julio Gallego-Delgado³

¹Department of Biological Sciences, Lehman College, City University of New York. Bronx, New York, NY, USA; PhD Program in Biochemistry, The Graduate Center, City University of New York, New York, NY, USA.

Seminars in nephrology

|May 15, 2025

概括

疟疾相关的急性损伤 (MAKI) 影响严重的疟疾病例,增加死亡率. 本综述考察了动物模型,以了解MAKI的病变发生和开发治疗方法.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
传染性疾病传染性疾病
翻译医学是一种翻译医学.

背景情况:

疟疾相关的急性损伤 (MAKI) 是Plasmodium falciparum疟疾的严重并发症.
MAKI影响40-60%的严重疟疾病例,显著增加死亡率,特别是在儿童中.
确切的MAKI的发病因子尚未完全理解,但涉及血液动力学,氧化和免疫因素.

研究的目的:

批判性地审查现有的动物模型来研究MAKI.
评估这些模型在复制人类MAKI时的优点和局限性.
强调需要改进的研究模型来开发有针对性的MAKI治疗.

主要方法:

对疟疾和损伤的动物模型现有文献的综述.
分析小鼠模型在探索免疫反应和生物标志物的实用性.
评估非人类灵长类动物模型对人类生理学相关性的MAKI.

主要成果:

小鼠模型提供了对免疫反应,生物标志物和治疗方法的洞察力,但并不能完全复制人类疟疾.
非人类灵长类动物模型为研究疟疾的脏表现提供了更大的生理复杂性.
目前的动物模型在充分捕捉人类MAKI条件方面存在局限性.

结论:

动物模型对于理解MAKI的潜在机制至关重要.
进一步开发动物模型对于推进MAKI研究至关重要.
改进的模型将促进对严重疟疾这一关键并发症的有效治疗方法的开发.

关键词:

疟疾:疟疾是一种疾病.急性脏损伤急性脏损伤疟疾动物模型动物模型鼠类动物 (murine) 是一种动物.非人类灵长类的灵长类.

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