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青少年无形性炎症性肌肉病对生长,发育和成熟的影响:系统性审查和元分析

Jessica C Guo¹, Olivia D Garisto², Jessie Cunningham³

¹J.C. Guo, BSc, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada.

The Journal of rheumatology

|May 15, 2025

概括

青春期炎症和免疫介导 (JIIM) 疾病可能会对生长和青春期发育产生负面影响,增长衰竭影响17.9%的患者. 需要进一步的研究来了解长期影响.

科学领域:

儿科内分泌学儿科内分泌学
发展生物学发展生物学
系统性审查和元分析

背景情况:

青少年炎症和免疫介导疾病 (JIIM) 越来越多地得到认可.
了解JIIM对成长和青春期发展的影响对于早期干预至关重要.

研究的目的:

系统地审查和评估JIIM对成长和青春期发展的影响.
量化JIIM儿童生长衰竭的患病率.

主要方法:

在多个数据库 (EMBASE,MEDLINE,PubMed,PsycINFO,Cochrane,Web of Science) 进行系统的文献搜索,截至2024年12月.
提取关于成长和青春期结果的数据.
针对使用 R 隐喻包的一致测量结果进行的元分析.

主要成果:

包括24项研究,来自5838个独特记录.
在18项研究中,有14项报告称身高下降或生长失败.
分析显示,生长衰竭的总体患病率为17.9% (95%CI). [10.7-25.0]). 在这个问题上.
五项研究报告了二次性特征或青春期的延迟,四项研究表明初潮的延迟.

结论:

JIIM可能会对发展产生重大不利影响,包括增长失败.
激素变化和延迟青春期的影响需要进一步研究.
在患有JIIM的儿童中,建议对内分泌异常进行积极查和治疗.

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