子周围神经元的化学遗传性破坏 投射到体中体 损害关联性学习
Wenliang Wang1, Mark A G Eldridge1,2, Tsuyoshi Setogawa1,3
1Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
概括
在灵长类动物中,学习新的视觉刺激-奖励关联依赖于从周围内皮层 (PRh) 到侧向中间尾状皮层 (rmCD) 的连接. 破坏这种途径会损害新学习,但不会损害记忆检索.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 灵长类动物的行为
背景情况:
- 灵长类动物利用刺激-奖励关联来做食决策.
- 鼻腔皮层 (Rh) 和正中尾皮层 (rmCD) 对于赋值视觉刺激至关重要.
- 在Rh项目中的5层神经元到rmCD.
研究的目的:
- 调查从Rh到rmCD的投射在学习和检索刺激-奖励关联中的因果作用.
- 为了确定这个系统中的特定路径是否对学习与检索至关重要.
主要方法:
- 在 rhesus 子中,Rh 到 rmCD 的第 5 层连接的可逆中断,使用单边的 Rh 损伤和抑制 DREADD.
- 通过微注射deschloroclozapine,静止从周围神经皮质 (PRh) 到rmCD的投射神经元.
- 评估对学习和新获得的刺激-奖励关联的影响.
主要成果:
- 对Rh到rmCD通路的中断对已建立的刺激-奖励关联的影响最小.
- 当Rh与rmCD的连接被破坏时,对新的刺激-奖励关联的学习受到损害.
- 特定于路径的PRh对rmCD投射神经元的沉默显著损害了新关联的学习.
结论:
- 新视觉刺激-奖励关联的学习,但不是它们的检索,关键地涉及从PRh到rmCD的投影神经元.
- 这一途径对于获得新的以价值为基础的指导行为关联至关重要.
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