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Updated: May 17, 2025

Real-time Imaging of Single Engineered RNA Transcripts in Living Cells Using Ratiometric Bimolecular Beacons
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Real-time Imaging of Single Engineered RNA Transcripts in Living Cells Using Ratiometric Bimolecular Beacons

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编程光编码DNA纳米花用于细胞特异性点多重复合微RNA成像

Fan Zhang1, Wenhao Dai1, Meiqin Zhang1

  • 1Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science & Technology Beijing, Beijing 100083, P. R. China.

Analytical chemistry
|May 15, 2025
PubMed
概括

这项研究引入了一种新的DNA纳米花系统,用于在活细胞中多重化微RNA (miRNA) 成像. 这种创新方法可以精确检测多个miRNA,用于发现疾病生物标志物.

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相关概念视频

Super-resolution Fluorescence Microscopy01:37

Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...
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