在Lidocaine贴片的外周应用后,在背部根结节中药物分布
Geng Xu1,2, Yongji Zhai1, Zhijun Yu3
1Department of Pain Medicine, Affiliated Hospital of Shandong Second Medical University, No.2428, Yuhe Road, 261041, Weifang, Shandong Province, People's Republic of China.
Scientific reports
|May 15, 2025
概括
在脊椎附近应用的利多卡因贴片实现了较高的背根瘤 (DRG) 度. 肋间间神经是利多卡因运输到DRG的关键,指导疼痛管理的最佳贴片放置.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 人体解剖学 解剖学 解剖学
背景情况:
- 局部利多卡因用于局部疼痛缓解.
- 了解从外围应用部位的药物分布对于优化治疗疗效至关重要.
- 背部根腺 (DRG) 是处理疼痛信号的关键部位,也是局部麻醉剂的目标.
研究的目的:
- 在外围贴片应用后,调查利多卡因在背部根 (DRG) 和脊髓中的分布和度.
- 确定利多卡因贴片的最佳放置,以最大限度地将药物输送到DRG.
- 阐明肋间神经在将利多卡因从皮肤运输到中枢神经系统中的作用.
主要方法:
- 子接受了5%的利多卡因贴片,应用于与肋间神经分布相关的各种外围位置 (椎,副,双侧).
- 在一些组中,切断了肋间神经,以评估它们在利多卡因运输中的作用.
- 在DRG,筋膜和脊髓中的利多卡因度使用高性能液态染色学在12小时的贴片应用后24小时量化.
主要成果:
- 利多卡因度在被治疗侧的DRG中显著更高,当贴片被应用在脊椎侧 (靠近脊柱) 时,与横侧应用相比.
- 相反的DRG里多卡因度比ipsilateral度更低.
- 切断肋间神经显著降低了DRG中的利多卡因度,表明神经是主要的运输途径.
结论:
- 肋间间神经是利多卡因从外围应用部位到背部根结核的主要运输途径.
- 为了获得有效的治疗结果,5%的利多卡因贴片应尽可能靠近脊柱,以最大限度地将药物输送到DRG.
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