在蓝藻细菌中自我维持的Kai蛋白昼夜振荡器的进化起源
Atsushi Mukaiyama1, Yoshihiko Furuike2,3, Kumiko Ito-Miwa4
1Department of Bioscience and Biotechnology, Fukui Prefectural University, Eiheiji, 910-1195, Japan. amukai@fpu.ac.jp.
Nature communications
|May 15, 2025
概括
古代的蓝藻细菌进化了自给自足的昼夜时钟,这对于氧气光合作用至关重要. 这种内部的生物钟,Kai振荡器,通过分子进化发展,优化能量获取.
科学领域:
- 时间生物学 时间生物学
- 进化生物学 进化生物学
- 生物化学 生物化学
背景情况:
- 光暗周期会影响自性蓝藻细菌的光合作用效率.
- 昼夜钟在早期的蓝藻细菌中的起源是理解光合作用进化的关键.
- 研究KaiC蛋白的进化历史对于理解昼夜节律性至关重要.
研究的目的:
- 确定蓝藻细菌中自我维持的Kai蛋白振荡器的进化起源.
- 为了确定古代蓝藻菌是否拥有与氧气光合作用的建立并发的昼夜时钟.
- 分析祖先Kai蛋白的功能和结构.
主要方法:
- 在现代蓝藻细菌中检查了KaiC蛋白的振荡.
- 分析了祖先Kai蛋白的功能和结构.
- 调查了全球氧化和雪球地球事件周围的分子进化.
主要成果:
- 祖先细菌中最早的双域KaiC缺乏节律性必需的因素.
- 祖先的Kai蛋白通过分子进化获得了节律性因素.
- 一个自我维持的昼夜振荡器是由氧化光合成蓝藻细菌的最近共同祖先继承的.
结论:
- 自主Kai蛋白振荡器是在古老的蓝藻细菌中演变的.
- 这种振荡器对于现代蓝藻细菌的最佳时间获取能量至关重要.
- 昼夜时钟是氧化光合作用进化的组成部分.
相关概念视频
Circadian Rhythms and Gene Regulation
4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
Biological Clocks and Seasonal Responses
34.5K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
34.5K
Eukaryotic Evolution
30.1K
The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
30.1K
Positive Regulator Molecules
5.3K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
5.3K
Prokaryotic Transcriptional Activators and Repressors
20.4K
The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
Transcription of prokaryotic...
Transcription of prokaryotic...
20.4K
Chromosome Structure
22.4K
A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
22.4K


