电磁波破坏了SARS-CoV-2尖端蛋白的稳定,并降低了SARS-CoV-2病毒样粒子 (SC2-VLP) 的感染力
Christina Pantoja1, Francisco M Acosta1, Skyler Granatir2
1Department of Biological Sciences, California State University Long Beach, Long Beach, CA, USA.
Scientific reports
|May 15, 2025
概括
2.5至3.5 GHz之间的电磁波可以减少严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染. 这项技术显示出对表面的消毒和防止包裹病毒传播的潜力.
科学领域:
- 病毒学 病毒学
- 电磁学 电磁学 电磁学 电磁学
- 公共卫生 公共卫生
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 传播仍然是一个全球卫生挑战.
- 电磁波提供了一种潜在的方法来禁用像SARS-CoV-2这样的病毒.
- 电磁波在减少SARS-CoV-2传染性的有效性需要进一步调查.
研究的目的:
- 确定能够中和SARS-CoV-2的特定电磁波频率.
- 研究电磁波对SARS-CoV-2病毒样粒子 (SC2-VLP) 的影响.
主要方法:
- 使用共平面波导 (CPW) 测试各种电磁波频率.
- 暴露于SC2-VLPs的电磁波频率在2.5至3.5GHz之间,电场为413V/m.
- 评估治疗SC2-VLP与向SARS-CoV-2Spike S1受体结合域 (RBD) 的抗体的结合亲和力.
主要成果:
- 2.5至3.5 GHz之间的频率显著降低了SC2-VLP的感染性.
- 暴露于3.1 GHz,在较小程度上是5.9 GHz,降低了SC2-VLP与RBD向抗体的结合.
- 在治疗后,斯派克蛋白,核囊蛋白,包膜蛋白或膜蛋白的总含量没有显著变化.
结论:
- 电磁波可以改变SARS-CoV-2尖端蛋白的构造,减少病毒的附着和进入.
- 这项研究提供了在针对SARS-CoV-2的卫生策略中使用电磁波的概念证明.
- 这些发现表明,电磁波在控制包裹病毒的传播方面具有潜在的应用.
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