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Updated: May 21, 2025

High-throughput Screening of Chemical Compounds to Elucidate Their Effects on Bacterial Persistence
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Published on: February 23, 2021

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一个共享的警报器-GTP开关控制细菌中持续形成的细菌

Danny K Fung1, Jessica T Barra1, Jin Yang1

  • 1Department of Bacteriology, University of Wisconsin, Madison, WI, USA.

Nature microbiology
|May 15, 2025
PubMed
概括

细菌的持久性,一种抗生素的生存策略,取决于警报激素瓜诺辛四/五酸 ((p) pGpp). 这种分子通过耗尽GTP触发转换到休眠状态,这是了解抗生素耐受性的关键发现.

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