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Updated: May 17, 2025

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
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Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

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SEC24D 枯竭因ATF6/TGF-β/Runx2 调节循环的失活而导致骨质生分化缺陷

Jing Zhang1, Kai Yang2, Wen-Qi Chen1

  • 1Prenatal Diagnosis Center, Shijiazhuang Obstetrics and Gynecology Hospital; Hebei Key Laboratory of Maternal and Fetal Medicine; Shijiazhuang Key Laboratory of Reproductive Health, Shijiazhuang, Hebei, China.

Communications biology
|May 15, 2025
PubMed
概括

在SEC24D基因的突变导致骨质不完善 (OI) 通过损害骨发育. 这项研究确定了新的SEC24D变异,并揭示了涉及ATF6/TGF-β通路的机制.

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