长期COVID和子宫内膜异位症:一个系统的审查和元分析
Alexandre Vallée1,2, Maxence Arutkin3,4, Pierre-François Ceccaldi5
1Department of Epidemiology and Public Health, Foch hospital, Suresnes, France. al.vallee@hopital-foch.com.
BMC women's health
|May 15, 2025
概括
长期COVID,在SARS-CoV-2感染后的一种持续性疾病,在患有子宫内膜异位症的女性中更为常见. 这项研究表明子宫内膜异位症与长期COVID风险增加之间存在联系.
科学领域:
- 生殖健康 生殖健康
- 传染性疾病 传染性疾病
- 慢性疾病 流行病学 流行病学
背景情况:
- 长期COVID,定义为SARS-CoV-2感染后的持续症状,影响了10-30%的感染者,并造成了严重的医疗负担.
- 子宫内膜异位症是一种慢性炎症状况,影响10%的生育年龄妇女,导致盆腔疼痛和不孕.
- 这两种情况都不成比例地影响女性,引发了对复杂健康挑战的担忧.
研究的目的:
- 调查子宫内膜异位症和长期COVID的发展之间的潜在关联.
- 综合现有的关于子宫内膜异位症患者长期COVID患病率的证据.
主要方法:
- 通过使用PubMed/Medline,Cochrane图书馆和Science Direct数据库进行了系统审查,直到2023年8月.
- 在独立选择和数据提取后,包括了两项截面研究,共有216,095名参与者.
- 使用随机效应模型进行的聚合分析评估了子宫内膜异位症和长期COVID之间的关联.
主要成果:
- 综合分析显示,子宫内膜异位症和长期COVID之间存在显著的关联 (综合RR=1.41 [1.31-1.52]).
- 研究中的异质性很低 (I2 = 29%),表明结果一致.
- 这种关联仍然具有统计学意义 (p < 0.001).
结论:
- 研究结果表明子宫内膜异位症与长期COVID的风险增加之间可能存在关联.
- 患有子宫内膜异位症的女性可能面临复杂的健康挑战,因为这两种疾病的患病率更高.
- 需要进一步研究强大的研究设计和多样化的群体,以证实这种关联并阐明潜在的机制.
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