预测De Novo转移性结肠癌患者的长期存活率的Nomograms:基于人口的分析
Rong Wang1, Junchi Cheng2, Wangyan Zhong3
1Department of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, 310022 Hangzhou, Zhejiang, China.
Annali italiani di chirurgia
|May 16, 2025
概括
这项研究确定了影响转移性结肠癌患者生存的关键因素. 一个新的名图准确地预测个人长期存活率,有助于风险分层,以更好地管理患者.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 临床预后 临床预后
背景情况:
- 转移性结肠癌在患者的治疗和生存方面构成了重大挑战.
- 准确的预后工具对于预测这些患者的长期结果至关重要.
研究的目的:
- 评估新发转移性结肠癌患者的整体存活率 (OS) 和癌症特异性存活率 (CSS).
- 开发和验证用于预测这一群体的长期存活率的预后性名ogram.
主要方法:
- 使用监测流行病学和最终结果 (SEER) 数据库 (2010-2015) 进行基于人口的队列分析.
- 包括6857名患有新发转移性结肠癌的患者,分为培训和验证组.
- 多变量考克斯回归分析以确定独立的预后因素.
主要成果:
- 组织学等级,年龄,T和N阶段,远程转移,围神经侵入,CEA水平,化疗和手术显著影响了OS和CSS.
- 种族是CSS的预测因素,但不是OS.
- 一个经过验证的预后名录显示,一致性指数 (C指数) 约为0.72,有效地根据风险对患者进行分层.
结论:
- 确定了影响新诊断的转移性结肠癌生存的关键预后因素.
- 开发了一种名谱,用于准确预测新发转移性结肠癌患者的个人长期存活率.
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