心理和临床因素调解COVID-19后刺激性肠综合征
Keren Hod1,2, Giovanni Marasco3,4, Luigi Colecchia3
1Department of Nutritional Sciences, School of Health Sciences, Ariel University, Ariel, Israel.
Neurogastroenterology and motility
|May 16, 2025
概括
COVID-19 感染增加了易发性肠综合征 (IBS) 的风险. 呼吸不良,抑郁和特定的胃肠道症状调解了这种联系,为COVID-19后IBS提供了潜在的干预目标.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- 感染COVID-19与患上刺激性肠综合征 (IBS) 的风险增加有关.
- 了解这种关联背后的机制对于有效管理至关重要.
- 以前的研究表明存在联系,但具体的途径需要进一步阐明.
研究的目的:
- 调查将COVID-19暴露与COVID-19后IBS发展联系在一起的调解因素.
- 确定在这种关系中起作用的特定心理和临床症状.
- 提供针对预防或治疗COVID-19后IBS的有针对性的干预措施的证据.
主要方法:
- 一个多中心队列研究的后期分析,涉及623名COVID-19和没有COVID-19的患者.
- 使用了ROME IV标准,胃肠道症状评级表 (GSRS) 和医院焦虑和抑郁量表 (HADS).
- 使用PROCESS宏观和Baron和Kenny的方法进行调解分析.
主要成果:
- COVID-19和IBS之间的关联显著受到基线呼吸障碍的调解.
- 胃肠道症状,如酸性反,饥饿疼痛,腹,腹部膨胀,以及在不同时间点增加的浮,均介于COVID-19-IBS联系.
- 感染后6个月和12个月,抑郁症成为显著的调解者.
结论:
- 心理 (抑郁症) 和临床 (胃肠道症状) 因素调解了COVID-19和IBS之间的关系.
- 这些调解者代表了旨在治疗或预防COVID-19后IBS的干预措施的潜在目标.
- 意识到COVID-19后持续的胃肠道症状对于及时诊断IBS至关重要.
相关概念视频
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