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Updated: Jun 13, 2025

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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合成和生物评估MEK/mTOR多功能抑制剂作为新型抗癌剂

Marcian E Van Dort1,2, Lucas McDonald1,2, Youngsoon Jang1,2

  • 1Center for Molecular Imaging, The University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.

Journal of medicinal chemistry
|May 16, 2025
PubMed
概括

针对MEK和mTOR信号通路的新型双重作用化合物显示出对癌症治疗的希望. 化合物LP-65在体外有效抑制了癌细胞的生长和迁移,并在小鼠模型中证明了治疗疗效.

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