多基因风险和营养摄入量对肥胖结果的相互作用:观察性研究的系统审查和元分析
Guiomar Masip1,2,3, Hannah Yang Han1, Tongzhu Meng1
1School of Human Nutrition, McGill University, Montreal, Quebec, Canada.
概括
肥胖遗传风险与营养摄入量之间的相互作用的证据有限. 需要更多的研究来了解饮食和多基因风险评分如何影响体重.
科学领域:
- 营养科学 营养科学
- 遗传学 是一个遗传学.
- 肥胖问题研究研究
背景情况:
- 饮食显著影响体重,并且可以改变对肥胖的遗传倾向.
- 了解基因饮食相互作用对于开发有效的肥胖预防和管理策略至关重要.
研究的目的:
- 对与肥胖有关的多基因风险和营养消耗之间的相互作用进行系统审查和元分析现有研究.
- 综合证据,以多基因风险评分 (PRS) 量化的遗传易感性如何与饮食因素相互作用,影响肥胖的结果.
主要方法:
- 在主要的科学数据库 (MEDLINE,EMBASE,Web of Science,Cochrane Library) 进行了全面的搜索.
- 包括观察性研究,检查PRS-营养摄入量对肥胖指标的相互作用.
- 随机效应的元分析集中在PRS与总脂肪和蛋白质摄入量对体重指数 (BMI) 的相互作用上.
主要成果:
- 分析了来自不同族群的26篇出版物,其中饮食脂肪和能量摄入量最常被报告与PRS相互作用.
- 分析显示,PRS和总脂肪或蛋白质摄入量在BMI上没有显著的相互作用.
- 研究质量往往很低,异质性很高,PRS主要来自欧洲祖先样本.
结论:
- 目前关于多基因风险和营养摄入量与肥胖之间的相互作用的证据稀缺且不一致.
- 研究质量和多基因风险评分表征的重大局限性需要进一步调查.
- 未来的研究应该旨在澄清遗传因素和肥胖的饮食模式之间的复杂关系.
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