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微量营养素和慢性疼痛:一个截面分析

Madison Goon¹, Natalie Schmidt¹, Deepak Berwal²

¹Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida, USA.

Pain practice : the official journal of World Institute of Pain

|May 16, 2025

概括

慢性疼痛与维生素D,维生素B12和叶酸水平较低有关. 严重的疼痛与较高的维生素D,C和缺乏相关,这表明微量营养素的补充可能有助于控制疼痛.

科学领域:

营养科学营养科学
疼痛医学医学疼痛医学
生物化学生物化学

背景情况:

微量营养素缺乏日益被认为是导致慢性疼痛发展的潜在因素.
了解血清微量营养素水平与慢性疼痛之间的关系对于有效的管理策略至关重要.

研究的目的:

研究患有和没有慢性疼痛的个体之间血清微量营养素水平的差异.
分析各种疼痛严重程度和人口群体之间的这些差异.

主要方法:

一项使用我们所有人的数据库进行的横截面研究分析了维生素D (25OH-D),C,B12,叶酸和的血清水平.
根据数值评分尺度得分,对象被分为没有疼痛,轻度/中度和严重疼痛组.
微量营养素水平被分为正常,缺乏或边缘缺乏,分析按性别和种族/种族分层.

主要成果:

患有严重慢性疼痛的个体与疼痛较小或没有疼痛的人相比,血清中25OH-D,B12和叶酸水平较低 (p < 0.001).
在严重疼痛组 (p <0.05) 观察到25OH-D,维生素C (男性) 和缺乏的更高发病率.
具体缺陷因种族/种族和性别而异,黑人和白人个体显示较低的25OH-D和叶酸,白人显示较低的B12.

结论:

血清中25OH-D,B12和叶酸水平较低,以及25OH-D,维生素C (男性) 和缺乏症增加,与慢性疼痛有关.
与亚洲人和西班牙裔人相比,这些关联在黑人和白人群体中更为明显.
微量营养素补充为影响和管理慢性疼痛疾病提供了潜在的治疗途径.

关键词:

慢性疼痛是一种慢性疼痛.叶酸是什么叶酸是什么叶酸是什么的含量是多少? 的含量是多少?微量营养素微量营养素维生素维生素维生素是一种

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