咖啡消费和多发性骨髓瘤之间的遗传关联由血代谢物介导:孟德尔的随机化研究
Shichong Lin1,2, Dan Zhou1, Hua Zhu1
1School of Smart Health Care (School of Health & Medical), Zhejiang Dongfang Polytechnic, Zhejiang, China.
Food & function
|May 16, 2025
概括
咖啡消费,包括各种形式的咖啡,如碎咖啡和即溶咖啡,与多发性骨髓瘤 (MM) 的风险增加有关. 特定的代谢物,hippurate和cinnamoylglycine,调解这种关系,可能是通过谷氨代谢.
科学领域:
- 遗传学和流行病学
- 代谢学 代谢学 代谢学
- 在瘤学瘤学.
背景情况:
- 多发性骨髓瘤 (MM) 发病率正在上升,与饮食和代谢障碍有关.
- 全基因组关联研究 (GWAS) 对于理解饮食,代谢物和MM因果关系至关重要.
- 研究这些关系可以阐明癌症进展中的生物机制.
研究的目的:
- 评估饮食模式,代谢物和多发性骨髓瘤 (MM) 风险之间的因果关系.
- 确定特定的代谢物,调解饮食对MM的影响.
- 探索新陈代谢途径在MM病变发生过程中的作用.
主要方法:
- 利用大规模的GWAS数据用于饮食,代谢学和MM.
- 进行了两样本的门德尔随机化 (MR) 分析,主要使用逆方差加权 (IVW) 方法.
- 进行了灵敏度,反向MR,调解和代谢途径分析,以进行可靠的验证.
主要成果:
- 不同的咖啡消费模式 (碎咖啡,速溶咖啡,脱咖啡因咖啡) 与MM风险增加有显著关联.
- 确定了19种血代谢物,1种血液/尿液生物标志物和4种与MM明显相关的血脂质.
- 鉴定出酸盐和氨基甘氨酸是咖啡消费对MM风险影响的关键媒介,特别是通过谷氨代谢.
结论:
- 这些发现支持咖啡消费对多发性骨髓瘤风险的不良因果影响.
- 希普酸,3-基希普酸和花糖氨酸在这种关系中起到关键的调解作用.
- 谷氨代谢途径与咖啡摄入影响的MM病变产生有关.
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