在中国人口中患有中风后抑郁症的患者的肠道微生物群:系统性审查和元分析
Qiaoling Li1, Yuejuan Zhang2, Xiaoqian Wang2
1Graduate School, Hunan University of Chinese Medicine, Changsha, China.
Frontiers in cellular and infection microbiology
|May 16, 2025
概括
脑卒中后抑郁症 (PSD) 患者表现出肠道微生物群 (GM) 组成和功能的改变. 这次元分析显示,与健康对照人群相比,PSD患者的α多样性增加和显著的微生物族群增加.
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 临床研究是临床研究.
背景情况:
- 越来越多的证据表明,中风后抑郁症 (PSD) 患者的肠道微生物群 (GM) 发生变化.
- 了解GM和PSD之间的关系对于潜在的治疗干预至关重要.
研究的目的:
- 系统地评估PSD与肠道微生物群之间的关联.
- 为了比较PSD患者,健康对照 (HC) 和中风患者之间的转基因组成和多样性.
主要方法:
- 一项对14项涉及1556个人的研究进行了系统性审查和元分析.
- 搜索了主要的数据库 (PubMed,科学网,Embase等) 在2024年4月17日之前.
- 分析了基因转基因α多样性和相对丰度在属,家族和属级别的差异.
主要成果:
- 与HC相比,PSD患者的α多样性显著增加 (Chao1,ACE,Shannon,Simpson指数).
- 特定的细菌类,包括Bacteroidota,Fusobacteriota和Pseudomonadota,在PSD患者中比HC更为丰富.
- 与中风组相比,HC中Bacillota的丰度更高,PSD患者的Lachnospira水平更低.
结论:
- 与健康对照人群相比,PSD患者的肠道微生物群α多样性较高.
- 在PSD患者和HC患者之间,在属,家族和属层面上存在转基因成分的显著差异.
- 微生物差异凸显了潜在的肠-大脑轴参与中风后抑郁症的可能性.
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