精神分裂症的神经内分泌特征:北上腺素和黑激素是有前途的生物标志物
Junwei Shen1, Xin Li2, Yinghua Zhong1
1Clinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, China.
Frontiers in endocrinology
|May 16, 2025
概括
大脑衍生神经营养因子 (BDNF) 不是精神分裂症 (SZ) 的可靠生物标志物. 上腺素和黑激素显示出更大的潜力作为诊断生物标志物,由于SZ患者的显著升高.
科学领域:
- 神经内分泌学神经内分泌学
- 代谢学 代谢学 代谢学
- 精神疾病 精神疾病
背景情况:
- 脑衍生神经营养因子 (BDNF) 是研究的精神分裂症神经内分泌标志物.
- 现有的关于BDNF在SZ中的研究提出了不一致的发现,限制了其临床实用性.
研究的目的:
- 研究BDNF作为精神分裂症生物标志物的实用性.
- 为了探索SZ的女性患者的代谢概况.
- 为了确定可靠的神经内分泌生物标志物SZ.
主要方法:
- 分析了来自24名女性SZ患者和25名健康对照者的血清样本.
- 使用气体染色体质谱法 (GC-MS) 和液体染色体质谱法 (LC-MS) 进行了代谢分析.
主要成果:
- 没有证明BDNF是SZ.的强有力的歧视性生物标志物.
- 在SZ患者和对照人群之间观察到79种代谢物 (GC-MS) 和419种代谢物 (LC-MS) 的显著差异.
- 在SZ患者中,上腺素和黑激素水平显著升高,显示出比BDNF更高的诊断潜力.
结论:
- 改变的代谢模式是女性SZ患者的特征.
- 黑色素和上腺素被确定为SZ的有前途的神经内分泌生物标志物.
- 这些发现凸显了黑激素和上腺素在精神障碍中的诊断价值和神经内分泌调节作用.
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