肠道微生物群的饮食指数与脆弱性之间的联系:一个横截面研究
Shouxin Wei1, Sijia Yu2, Meng Sun1
1Department of Gastrointestinal Surgery, Suining Central Hospital, Suining, China.
Frontiers in nutrition
|May 16, 2025
概括
肠道微生物群的饮食指数 (DI-GM) 与脆弱性风险较低有关. 这种饮食方法,以及像白蛋白和HDL这样的关键生物标志物,可能有助于减少脆弱性.
科学领域:
- 老年学是一门学科.
- 营养科学 营养科学
- 微生物组研究 微生物组研究
背景情况:
- 脆弱性对患者的福祉和医疗保健成本产生重大影响.
- 肠道微生物群的饮食指数 (DI-GM) 是一种新的饮食评估工具.
- DI-GM与脆弱性之间的关系需要进一步调查.
研究的目的:
- 检查肠道微生物群饮食指数 (DI-GM) 与脆弱性之间的关联.
- 探索DI-GM-脆弱性关系中的潜在调解因素.
主要方法:
- 利用了2007-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 采用多变量加权后勤回归和限制立方线 (RCS).
- 进行子组和调解分析,以调查影响因素和途径.
主要成果:
- 在DI-GM和虚弱风险 (OR=0.940) 之间发现了显著的反向关联.
- 更高的DI-GM摄入量表明,剂量反应降低了虚弱风险,最高四分位数显示21.6%的下降.
- 白蛋白和高密度脂蛋白 (HDL) 显著调解了这种关联,分别解释了30.34%和9.05%的效果.
结论:
- 肠道微生物群的饮食指数 (DI-GM) 与脆弱性有负面关联.
- 专蛋白和高脂蛋白是DI-GM-脆弱性通路中的关键调解剂.
- 通过DI-GM提高饮食质量可能是预防虚弱的可行策略.
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