新出现的病原体:医院中Kodamaea ohmeri感染的低估风险
Shuang-Jie Wang1, Xia Yu2, Jia-Hui Liang1
1Department of Laboratory, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Frontiers in microbiology
|May 16, 2025
概括
科达梅亚 (Kodamaea ohmeri) 是一种新兴的病原体,引起罕见但严重的感染,特别是在新生儿身上. 这项研究强调了在疫情期间识别抗可纳抗菌株的挑战,强调了改善诊断的必要性.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 科达梅亚 (Kodamaea ohmeri) 是一种新兴的人类病原体,其死亡率很高,特别是在新生儿中.
- 由于识别挑战,K. ohmeri感染在医院爆发期间可能被低估.
研究的目的:
- 为了确定检测K. ohmeri的诊断准确性,在候选血症中.
- 为了调查K.ohmeri.在医院可能爆发的疫情.
主要方法:
- 对六个K. ohmeri分离物的回顾性研究,最初被误认为是Candida dubliniensis.
- 用临床数据和全基因组测序来分析疫情菌株.
- 进行了抗微生物敏感性测试,包括最小抑制度 (MICs).
主要成果:
- 隔离物表现出非典型的特征和低MICs为安福特里辛B,5-细胞素和类甘,但高MICs为可纳.
- 第4名患者对三醇的MIC高.
- 全基因组测序将分离物组分为三个分类,其中分类1表明患者1和2的共同来源.
结论:
- 需要提高对K.ohmeri感染的认识,包括新出现的抗可纳菌株.
- 应该承认K.ohmeri是一种潜在的医院病原体,能够引起疫情.
- 如果无法识别这些新出现的病原体,可能会产生严重的后果.
相关概念视频
Factors Affecting the Risk of Infection
10.6K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
10.6K
Antibiotic Selection
52.0K
Overview
52.0K
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Transmission-based Precautions II: Airborne and Protective Environment
1.2K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.2K
Hypothesis: Accept or Fail to Reject?
27.4K
The outcome of any hypothesis testing leads to rejecting or not rejecting the null hypothesis. This decision is taken based on the analysis of the data, an appropriate test statistic, an appropriate confidence level, the critical values, and P-values. However, when the evidence suggests that the null hypothesis cannot be rejected, is it right to say, 'Accept' the null hypothesis?
There are two ways to indicate that the null hypothesis is not rejected. 'Accept' the null...
There are two ways to indicate that the null hypothesis is not rejected. 'Accept' the null...
27.4K
Infection
6.9K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
6.9K


