乳杆菌重组微生物组以对抗肺动脉高血压中由炎症引起的右心室功能障碍
Sasha Z Prisco1, Madelyn Blake1, Felipe Kazmirczak1
1Lillehei Heart Institute, Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis (S.Z.P., M.B., F.K., R.M., B.P.K., L.M.H., M.K., N.V., J.B.M., T.T., K.W.P.).
Circulation. Heart failure
|May 16, 2025
概括
乳酸菌补充剂在肺动脉高血压 (PAH) 模型中改善了肠道健康并减少了炎症. 这种方法通过准GP130微管轴来恢复右心室 (RV) 功能,为RV功能障碍提供治疗潜力.
科学领域:
- 微生物学 微生物学
- 心血管生物学 心血管生物学
- 胃肠病学 胃肠病学
背景情况:
- 在肺动脉高血压 (PAH) 中,炎症会损害右心室 (RV) 功能.
- 在动物PAH中,GP130信号驱动病态微管重塑和RV功能障碍.
- 肠道微生物组在RV衰竭中的GP130微管轴中的作用尚未被探索.
研究的目的:
- 为了研究调节肠道微生物群对VR失灵中的GP130微管轴的影响.
- 评估是否可以补充Lactobacillus rhamnosus可以改善PAH的RV功能障碍.
主要方法:
- 患有单克罗他林诱导的PAH的老鼠通过口腔 gavage 接受了Lactobacillus rhamnosus.
- 使用元基因组学和ITS2测序分析了便微生物组合.
- 血清蛋白质组学,RV免疫污点和先进显微镜评估了分子和细胞的变化.
- 使用心声回声和压力-体积循环评估RV功能;患者数据将乳酸菌丰度与RV功能相关联.
主要成果:
- 乳酸菌的使用重组了肠道的微生物和真菌生物组,改善了肠道的健康状况,降低了肠道的透性.
- 血清蛋白质组显示了乳酸菌调节的全身炎症和减少GP130连接体.
- 通过Lactobacillus纠正RV心肌细胞微管重塑抑制GP130信号传递,并改善了大鼠的RV功能.
- 患有PAH和可检测的便Lactobacillus的患者表现出优异的RV功能.
结论:
- 乳酸菌补充剂重组肠道微生物群,增强肠道健康,减轻全身炎症.
- 这种益生菌干预减少了GP130连接体,并减轻了RV心肌细胞微管重塑.
- 一个新的微生物组-炎症-微管轴被确定为PAH中RV功能障碍的治疗相关性.
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