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Updated: Jun 19, 2026

Primer-Free Aptamer Selection Using A Random DNA Library
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对阿普坦酶序列的四重复性倾向的分析

Anne Cucchiarini1, Michaela Dobrovolná2,3, Václav Brázda2,3

  • 1Laboratoire d'Optique et Biosciences, Ecole Polytechnique, CNRS, INSERM, Institut Polytechnique de Paris, 91120 Palaiseau, France.

Nucleic acids research
|May 16, 2025
PubMed
概括

亚体,DNA或RNA分子,经常形成G-四重复 (G4) 结构,这是一个经常被忽视的发现. 这项研究揭示了大量的体具有G4图案,需要重新评估它们的结构潜力.

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Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis pathway,...