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限制光谱成像作为前列腺癌的定量生物标志物,具有可靠的积极预测值.

Mariluz Rojo Domingo^1,2, Deondre D Do^1,2, Christopher C Conlin³

¹Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.

The Journal of urology

|May 16, 2025

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概括

限制谱成像限制得分 (RSIrs) 为临床显著前列腺癌 (csPCa) 检测提供了一个客观的生物标志物. 这种定量指标的性能与PI-RADS相当,并且优于ADC,改善了csPCa的诊断,而不需要放射学专业知识.

科学领域:

放射学和医学成像学医学成像学
生物物理学的生物物理.
在瘤学瘤学.

背景情况:

对于临床显著的前列腺癌 (csPCa) 的前列腺成像报告和数据系统 (PI-RADS) 有可变的预测价值.
限制光谱成像限制得分 (RSIrs) 是一种新的,基于生物物理的,来自扩散MRI的度量.
作为csPCa检测的客观生物标志物,RSIrs具有潜力.

研究的目的:

评估RSIrs在一个大,异构的数据集中的患者级csPCa检测的性能.
将RSI的表现与明显扩散系数 (ADC) 和PI-RADS.比较.
评估将RSIrs与临床和成像参数相结合以提高csPCa检测的实用性.

主要方法:

来自7个中心1892名患者的前列腺MRI数据 (2016年1月 - 2024年3月).
使用最大RSIrs.计算患者级的csPCa概率.
对 csPCa (GG ≥2) 的 RSIrs,ADC 和 PI-RADS 的检测性能 (AUC) 的比较.
多变量回归分析将RSIrs与临床因素结合起来.

主要成果:

csPCa的概率随着较高的RSIrs.增加.

关键词:

扩散加权成像是一种扩散加权成像.前列腺癌检测检测器前列腺核磁共振成像定量生物标志物定量生物标志物限制频谱成像技术的使用

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在未经活检的患者中,AUC为RSIrs=0.73,ADC=0.54,PI-RADS=0.75.

RSIrs显著优于ADC (P < .01) 的表现,并且与PI-RADS (P = .31) 的表现相当.

综合RSIrs和PI-RADS的表现优于单独的;最好的模型包括RSIrs,PI-RADS,年龄和PSA密度.

结论:

RSIrs是一个准确,可靠的定量生物标志物,用于csPCa检测.
RSIrs的表现比ADC更好,与PI-RADS相提并论.
RSIrs提供客观的csPCa概率估计,减少对放射科医生的专业知识的依赖.