多种围产期特征影响了母亲糖尿病状况与新生儿早期肠道微生物群之间的关联
Cheng Liu1, Wei Zheng1, Jia Wang1
1Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
mSphere
|May 16, 2025
概括
孕产妇妊娠糖尿病 (GDM) 与新生儿肠道微生物群的改变有关,细菌丰富度不同,而不是组成. 围产期因素显著影响这些变化,强调了它们在研究中的重要性.
科学领域:
- 微生物组研究 微生物组研究
- 新生儿健康 新生儿健康
- 生殖内分泌学 生殖内分泌学
背景情况:
- 母胎妊娠糖尿病 (GDM) 越来越多地被认为对新生儿肠道微生物群的潜在影响.
- 现有研究表明存在差异,可能是由于未考虑的产前和产周因素影响了最初的微生物殖民.
- 了解这些影响对于准确解释GDM对婴儿肠道健康的影响至关重要.
研究的目的:
- 调查各种围产期特征如何改变母亲妊娠糖尿病 (GDM) 与新生儿早期肠道微生物群之间的关联.
- 用16S rRNA基因片序列测序分析样本,以比较微生物多样性和组成.
- 确定影响有或没有GDM的母亲新生儿肠道微生物群分化的特定围产因素.
主要方法:
- 一项嵌套病例控制研究,涉及247对母婴 (114 GDM,133对照).
- 在出生后24小时内采集的甲样本通过16S rRNA基因安普利康测序进行分析.
- 统计分析包括多样性指数 (Chao1),主要坐标分析 (PCoA) 和线性判别分析 (LDA) 以基于GDM状态和其他围产因素来比较微生物群.
主要成果:
- 患有GDM的母亲产生的新生儿表现出较低的α多样性 (Chao1指数,P=0.0235).
- 根据GDM状态分组的样只具有未加权的UniFrac距离 (R2=0.011,P=0.003),表明微妙的差异.
- 在GDM和对照组之间观察到81种类型的显著差异;其他产前因素,如母亲的BMI,年龄,妊娠期体重增加,分娩方式,新生儿性别和出生体重也显著影响了微生物多样性和类型.
结论:
- 患有GDM的母亲和正常血糖的母亲的新生儿的肠道微生物组合相似,但在细菌丰富度上有所不同.
- 同时的围产特征,包括孕前母亲的BMI,年龄,妊娠期体重增加和新生儿因素 (分娩方式,性别,出生体重),显著影响新生儿肠道微生物群的多样性和组成.
- 调查GDM与新生儿肠道微生物群相关性的未来研究必须考虑这些重要的混周产期因素.
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