转移性转移模式的变化与转移性割耐药前列腺癌中循环瘤DNA的动态有关
Vincenza Conteduca1, Emanuela Scarpi2, Alice Rossi3
1Unit of Medical Oncology and Biomolecular Therapy, Department of Medical and Surgical Sciences, University of Foggia, Policlinico Riuniti, 71122 Foggia, Italy.
The oncologist
|May 16, 2025
概括
循环瘤DNA (ctDNA) 可以预测转移性割抵抗性前列腺癌 (mCRPC) 的治疗反应. 早期ctDNA水平的变化,特别是骨转移,与疾病进展和患者生存结果相关.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 癌症生物标志物 癌症生物标志物
背景情况:
- 循环瘤DNA (ctDNA) 是治疗疗效的早期指标之一,用于治疗雄激素受体信号抑制剂 (ARSI).
- 这项研究调查了ctDNA是否可以补充成像来预测转移负担和转移性割抵抗性前列腺癌 (mCRPC) 的放射性进展.
研究的目的:
- 为了确定ctDNA分析是否可以补充常规成像来预测转移负担.
- 评估ctDNA在预测放射性进展和ARSI治疗的mCRPC患者的患者结局方面的有用性.
主要方法:
- 来自112名mCRPC患者的潜在血样本采集.
- 针对下一代测序来测量ctDNA分数.
- 传统的成像,根据前列腺癌工作组3标准,记录放射性证据.
主要成果:
- 骨转移模式与基线,治疗期间和进展时的中位数ctDNA水平显著相关 (P < .0001).
- 骨病恶化患者 (31.2%) 的早期ctDNA升高明显高于稳定骨病患者 (11.1%) (P < .0001).
- 在ARSI治疗3个月内从低ctDNA过渡到高ctDNA预测了整体生存 (OS),而持续高ctDNA预测了无进展生存 (PFS).
结论:
- 早期的ctDNA变异反映了ARSI治疗期间转移负担的变化,特别是骨转移模式的变化.
- ctDNA分析有助于跟踪疾病进展和预测mCRPC中的患者结果.
- 在mCRPC中,ctDNA作为监测治疗反应和预后的宝贵生物标志物.
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