在核酸类比治疗期间HBV生物标志物的动力学:一项为期14年的研究
Florian van Bömmel1, Elisabetta Degasperi2, Alena van Bömmel3
1Department of Medicine II, Division of Hepatology, Leipzig University Medical Center, Leipzig, Germany.
Hepatology communications
|May 16, 2025
概括
长期的核胺类同类 (NA) 治疗慢性乙型肝炎 (CHB) 增加了实现功能治愈生物标志物的可能性. 这些生物标志物,包括HBsAg,HBV RNA和HBcrAg,对于监测治疗反应和指导CHB患者停止NA治疗至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 生物标志物研究 生物标志物研究
背景情况:
- 慢性乙型肝炎 (CHB) 的治疗包括核酸类比 (NA) 疗法.
- 乙型肝炎表面抗原 (HBsAg),HBVRNA和乙型肝炎核心相关抗原 (HBcrAg) 是关键的生物标志物.
- 评估这些生物标志物有助于预测治疗反应和潜在的NA中止.
研究的目的:
- 研究HBsAg,HBVRNA和HBcr.Ag的长期动力学.
- 评估这些生物标志物作为CHB患者中断NA后功能治愈的预测因素.
- 在延长NA治疗期间 (长达14年) 分析生物标志物趋势.
主要方法:
- 对前性队列研究的回顾性分析.
- 包括96名HBeAg阴性CHB患者 (HBV基因型D) 在诺福维尔二氧化烟酸治疗中.
- 在384个血清样本中测量HBsAg,HBV RNA和HBcrAg;定义功能治愈终点.
主要成果:
- 大多数患者最初可以检测到HBV RNA和HBcrAg.
- 可检测的HBVRNA在8-14年的NA治疗中显著下降.
- 功能治愈的综合生物标志物终点在长期NA治疗期间逐渐增加.
结论:
- 长期的NA治疗与改善的HBV生物标志物概况有关.
- 达到特定的HBsAg,HBVRNA和HBcrAg水平表明功能治愈的可能性更高.
- 这些生物标志物对于监测接受延长NA治疗的CHB患者非常有价值.
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