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术前18F-氧葡萄糖正子发射断层扫描参数可以预测乳腺癌的分子亚型吗?

Mehmet Esat Duymus¹, Abdullah Bulgurcu², Umit Ogur³

¹Istinye University Faculty of Medicine, Medical Park Gaziosmanpaşa Hospital, Hatay, Turkey.

Indian journal of cancer

|May 16, 2025

概括

来自18F-FDG PET-CT扫描的最大标准化吸收值 (SUVmax) 和总损伤糖解 (TLG) 可以帮助区分侵入性乳腺癌亚型. 这些代谢参数有助于区分三阴性和激素受体阳性瘤.

科学领域:

在瘤学瘤学.
核医学是一种核医学.
无线电学 (Radiomics) 是一种放射学.

背景情况:

对侵袭性乳腺癌 (IBC) 分子亚型的准确分类对于治疗选择至关重要.
来自18F-FDG PET-CT成像的代谢参数为非侵入性亚型化提供了潜力.

研究的目的:

评估代谢参数的预测值,包括SUVmax,MTV和TLG,用于识别IBC分子亚型.
将这些代谢特征与临床病理学发现和受体表达状态 (ER,PR,HER-2) 相关联.

主要方法:

对112名接受了手术前18F-FDG PET-CT的IBC患者进行了回顾性分析.
评估SUVmax,MTV和TLG与ER,PR和HER-2表达的关系.
统计分析以确定分子亚型之间的显著差异.

主要成果:

在分子亚型中观察到原发性瘤SUVmax和TLG的显著差异 (分别P < 0.001和P = 0.001).
轴心淋巴结转移SUVmax在各组之间显示出显著的差异 (P = 0.014).
在初级瘤或淋巴结的代谢性瘤体积 (MTV) 中没有发现显著差异.

结论:

主要瘤SUVmax可以区分三阴性乳腺癌和其他亚型.
主要瘤TLG有效地区分激素受体阳性 (HR+) 乳腺癌患者.
18F-FDG PET-CT代谢参数显示,对侵袭性乳腺癌的非侵袭性分子亚型有希望.

关键词:

乳腺癌乳腺癌乳腺癌代谢性瘤的体积和体积.分子亚型分子亚型标准化吸收值是标准化的吸收值.总的损伤糖解.

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