胆基离子凝对万科米辛化通过皮肤传递的影响
Deepanjan Datta1,2, Sony Priyanka Bandi2, Venkata Vamsi Krishna Venuganti2
1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104 Karnataka State, India.
Molecular pharmaceutics
|May 16, 2025
概括
基于胆的离子液体 (ILs) 增强了万科米辛化 (VH) 的通过皮肤传递. CAGE-Pluronic F-127离子凝显示出局部VH给药的显著潜力,改善皮肤透和保留.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 离子液体 (ILs) 对于高分子量药物来说,具有优越的通过皮肤吸收能力.
- 友性类药物,如万科米辛化 (VH),在皮肤上使用时面临挑战.
- VH是一种糖抗生素,具有高分子量 (1449达) 和水溶性.
研究的目的:
- 使用基于胆的ILs量化VH通过皮的透.
- 评估不同IL配方在增强VH皮肤透性的有效性.
- 开发和描述一种用于改善VH局部输送的离子凝配方.
主要方法:
- 基于胆的ILs的配方:胆甘 (CAGE),胆二碳酸与油酸 (CO) 以及胆二碳酸与棕酸 (CP).
- 使用NMR,XRD,DSC,FTIR和泽塔潜力的ILs的表征.
- 在完整的和带脱皮的猪皮肤上进行了ex vivo皮肤透研究.
- 一个CAGE-Pluronic F-127离子凝 (CAGE-P) 的制造和特征.
主要成果:
- 洁净的VH显示没有穿透切除的猪皮.
- CO和CP配方显著改善了VH在皮肤透率 (6729±437μg/cm2) 和在皮肤上保持 (3892±215μg/g).
- 在脱皮皮肤 (7543 ± 585 微克/厘米2) 和完整皮肤 (369 ± 41 微克/厘米2) 中,CAGE-P 离子凝显示了最高的 VH 透率.
- 生物物理研究表明,CAGE和CAGE-P配方对皮肤屏障特性有显著的改变.
结论:
- 基于胆的ILs,特别是CAGE,有效地增强VH通过皮的透.
- 开发的CAGE-Pluronic F-127离子凝 (CAGE-P) 是一种有前途且高效的局部配方,用于输送VH.
- 这种离子凝配方可促进本地和全身VH的管理.
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