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Updated: May 17, 2025

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
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Published on: January 17, 2012

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一种多二型皮相仿剂破坏了Grb2 SH3C域蛋白与蛋白相互作用,这与乳腺癌有关

James Luccarelli1, Philip C Simister2, Andrew D Hamilton1

  • 1University of Oxford, Department of Chemistry, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Chembiochem : a European journal of chemical biology
|May 16, 2025
PubMed
概括

研究人员开发了一种新的非性支架,模仿聚二烯 (PPII) 螺旋,有效地破坏了参与癌细胞生长的关键蛋白质-蛋白质相互作用 (PPI). 这一突破通过准关键信号通路,为癌症提供了新的治疗策略.

关键词:
在HER2中,HER2是HER2.蛋白质与蛋白质的相互作用在SH3域名中,SH3域名是SH3域名.模仿模仿模仿的模仿二级结构是二级结构的二次结构.

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