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Updated: May 6, 2026

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化IgG抗炎活性的分子决定因素

Sunny L Sneed1, Elizabeth A Strandberg1, Ana F S Laureano1

  • 1Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129.

Proceedings of the National Academy of Sciences of the United States of America
|May 16, 2025
PubMed
概括

对IgG1和IgG3抗体的化赋予了抗炎活性,这取决于DC-SIGN/SIGN-R1. 在CH2域中特定的氨基酸残留决定了这种效应,使治疗IgG子类的工程成为可能.

关键词:
Fc马受体的使用方法这是一种抗炎药物.糖基化,化,化.免疫球蛋白是一种免疫球蛋白.

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