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关于撒哈拉以南非洲疟疾的全基因组关联研究:范围审查

Morine Akoth¹, John Odhiambo¹, Bernard Omolo^1,2,3

¹Strathmore Institute of Mathematical Sciences, Strathmore University, Ole Sangale Road, Nairobi, Kenya.

|May 16, 2025

概括

关于撒哈拉以南非洲疟疾的全基因组关联研究 (GWAS) 是有限的. 本次审查强调需要更多的研究来了解影响该地区疟疾易感性,耐药性和严重性的遗传因素.

科学领域:

遗传学遗传学是一个
流行病学流行病学
公共卫生公共卫生

背景情况:

疟疾是撒哈拉以南非洲 (SSA) 死亡的主要原因.
在SSA中对疟疾全基因组关联研究 (GWAS) 的现有研究需要全面地图.
了解遗传因素对于疟疾控制策略至关重要.

研究的目的:

在撒哈拉以南非洲 (SSA) 进行的现有疟疾全基因组关联研究 (GWAS) 的证据进行映射和合成.
为了确定SSA地区疟疾GWAS的研究差距和趋势.
在SSA中为疟疾遗传学的未来研究方向提供信息.

主要方法:

采用了范围审查方法,搜索主要数据库 (谷歌学者,PubMed,Scopus,科学网) 在2000年1月至2024年12月期间发表的研究.
数据的提取和综合是由两个独立的审稿人使用既定的包含-排除标准和包括R,SRplot,Excel和Zotero在内的软件进行的.
总共有89项相关研究被确定和分析.

主要成果:

大多数纳入的研究 (n=42) 使用了病例控制设计,研究在2012年之后显著增加.
主要研究地点包括肯尼亚 (n=23),冈比亚 (n=18),喀麦隆 (n=15) 和坦桑尼亚 (n=9).
研究主要研究与疟疾易感性,耐药性和严重性相关的遗传变异.

结论:

病例控制研究,特别是在肯尼亚和冈比亚,报告了与疟疾结果相关的显著遗传变异.
在SSA中,全基因组关联研究 (GWAS) 对疟疾的稀缺性显著,使用基于模型的方法的人数更少.
对于在SSA扩展的全基因组疟疾研究存在重大需求,以解决知识差距.

关键词:

全基因组关联研究研究.撒哈拉以南非洲的范围审查.疟疾疟疾是一种疾病.

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